T-type calcium channels in synaptic plasticity
نویسندگان
چکیده
منابع مشابه
Involvement of voltage-dependent calcium channels in synaptic plasticity of the rat visual cortex
In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-typ...
متن کاملInvolvement of voltage-dependent calcium channels in synaptic plasticity of the rat visual cortex
In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-typ...
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Voltage-gated Ca(2+) channels in presynaptic nerve terminals initiate neurotransmitter release in response to depolarization by action potentials from the nerve axon. The strength of synaptic transmission is dependent on the third to fourth power of Ca(2+) entry, placing the Ca(2+) channels in a unique position for regulation of synaptic strength. Short-term synaptic plasticity regulates the st...
متن کاملT‐type calcium channels contribute to NMDA receptor independent synaptic plasticity in hippocampal regular‐spiking oriens‐alveus interneurons
KEY POINTS Regular-spiking interneurons in the hippocampal stratum oriens exhibit a form of long-term potentiation of excitatory transmission that is independent of NMDA receptors but requires co-activation of Ca2+ -permeable AMPA receptors and group I metabotropic glutamate receptors. We show that T-type Ca2+ channels are present in such interneurons. Blockade of T-type currents prevents the i...
متن کاملSynaptic targeting of N-type calcium channels in hippocampal neurons.
N-type calcium (Ca2+) channels play a critical role in synaptic function, but the mechanisms responsible for their targeting in neurons are poorly understood. N-type channels are formed by an alpha(1B) (Ca(V)2.2) pore-forming subunit associated with beta and alpha2delta auxiliary subunits. By expressing epitope-tagged recombinant alpha1B subunits in rat hippocampal neuronal cultures, we demonst...
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ژورنال
عنوان ژورنال: Channels
سال: 2016
ISSN: 1933-6950,1933-6969
DOI: 10.1080/19336950.2016.1238992